Will the lifetime of my engine be affected in a bad way after the optimization?

The simple answer is: No!

The power reserves of the engine are so large, that you don't have to expect more engine wear. We optimize the settings of the engine without exceeding the limits of the reliability. If the car is driven normally there are no decreases of the lifetime! If the car is driven very hard (racing situation), the approx. reduced lifetime is about 3-5 %. That would mean Fe. 480.000 km (300.000 miles) instead of 500.000 km (312.000 miles).